Hadamard editing of glutathione and macromolecule-suppressed GABA
نویسندگان
چکیده
منابع مشابه
Brain GABA editing without macromolecule contamination.
A new scheme is proposed to edit the 3.0 ppm GABA resonance without macromolecule (MM) contamination. Like previous difference spectroscopy approaches, the new scheme manipulates J-modulation of this signal using a selective editing pulse. The elimination of undesirable MM contribution at 3.0 ppm is obtained by applying this pulse symmetrically about the J-coupled MM resonance, at 1.7 ppm, in t...
متن کاملGABA editing at 3T with Macromolecule Suppression: MEGA-SPECIAL
Introduction. One commonly used method for in-vivo magnetic resonance spectroscopy (MRS) detection of γ-aminobutyric acid (GABA) is the MEGA-PRESS technique [1], which enables direct observation of the GABA resonance at 3.02 ppm. Unfortunately, direct quantification of GABA using MEGA-PRESS is complicated by co-editing of macromolecule (MM) signals, which also resonate at 3.02 ppm [2]. Two meth...
متن کاملIn Vivo Evaluation of the Concentration of Macromolecule Species involved in GABA Editing
C. Choi, N. J. Coupland, P. P. Bhardwaj, N. Malykhin, D. Gheorghiu, P. S. Allen Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada, Psychiatry, University of Alberta, Edmonton, Alberta, Canada INTRODUCTION γ-Aminobutyric acid (GABA) can be detected noninvasively in human brain by proton NMR spectroscopy. Spectral editing is commonly used to overcome the spectral overlap of...
متن کاملGABA editing with macromolecule suppression using an improved MEGA-SPECIAL sequence.
PURPOSE The most common γ-aminobutyric-acid (GABA) editing approach, MEGA-PRESS, uses J-editing to measure GABA distinct from larger overlapping metabolites, but suffers contamination from coedited macromolecules (MMs) comprising 40 to 60% of the observed signal. MEGA-SPECIAL is an alternative method with better MM suppression, but is not widely used primarily because of its relatively poor spa...
متن کاملSimultaneous edited MRS of GABA and glutathione
Edited MRS allows the detection of low-concentration metabolites, whose signals are not resolved in the MR spectrum. Tailored acquisitions can be designed to detect, for example, the inhibitory neurotransmitter γ-aminobutyric acid (GABA), or the reduction-oxidation (redox) compound glutathione (GSH), and single-voxel edited experiments are generally acquired at a rate of one metabolite-per-expe...
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ژورنال
عنوان ژورنال: NMR in Biomedicine
سال: 2017
ISSN: 0952-3480
DOI: 10.1002/nbm.3844